Benfotiamine With Thiamine, 100 mg, 120 vegetarian capsules

For example, the enzyme transketolase is critical to blood sugar metabolism. Like many enzymes, transketolase requires a co-factor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water soluble, which makes it less available to the interior of the cell. Benfotiamine is fat soluble and can easily penetrate into the inside of cells. It is also more bioavailable than the water-soluble thiamine.

In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage.12 Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions.12 

In addition, benfotiamine reduces the advanced glycation end products (AGEs) formation caused by excessively high glucose/fructose levels, especially inside endothelial, retinal, kidney and nerve cells, and maintains healthy endothelial function.13-21* Benfotiamine with thiamine is a low-cost dietary supplement that can help maintain  already-normal blood sugar levels and support the health of the nerves, kidneys, eyes, blood vessels, and heart.*